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Annotation


Matsuoka Y, Saito M, LaFrancois J, Saito M, Gaynor K, Olm V, Wang L, Casey E, Lu Y, Shiratori C, Lemere C, Duff K. Novel therapeutic approach for the treatment of Alzheimer's disease by peripheral administration of agents with an affinity to beta-amyloid. J Neurosci. 2003 Jan 1;23(1):29-33. PubMed Abstract

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REAGENTS/MATERIAL:

Transgenic mutant APP(K670N,M671L)Tg2576 and mutant PS-1 (M146L) line 6.2 were crossed to generate PS/APP offspring.

ELISA assay for amyloid-beta 40 and 42 used antibodies from Janssen Pharmaceuticals.

For histology on mouse brains biotinylated anti-amyloid-beta40/42 (Clone 6E10, Signet) was used.

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