Hippocampal neurons of mice deficient in DNA-dependent protein kinase exhibit increased vulnerability to DNA damage, oxidative stress and excitotoxicity. - AlzForum Alzheimer Research Paper of the Week


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Annotation

	Culmsee C, Bondada S, Mattson MP. Hippocampal neurons of mice deficient in DNA-dependent protein kinase exhibit increased vulnerability to DNA damage, oxidative stress and excitotoxicity. Brain Res Mol Brain Res. 2001 Mar 5;87(2):257-62. PubMed Abstract

	Comments on Related News

	Related News: Exploring Genome Fragmentation in Neurodegeneration Comment by: Luc Buee
	Submitted 23 February 2013 \| Permalink	Posted 26 February 2013
	We all agree that DNA damage increases with aging. Many proteins described in neurodegenerative disorders may be involved in this process. A key one is once again forgotten: tau. References: Sultan A, Nesslany F, Violet M, Bégard S, Loyens A, Talahari S, Mansuroglu Z, Marzin D, Sergeant N, Humez S, Colin M, Bonnefoy E, Buée L, Galas MC. Nuclear tau, a key player in neuronal DNA protection. J Biol Chem. 2011 Feb 11;286(6):4566-75. Abstract View all comments by Luc Buee

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