The UCH-L1 gene encodes two opposing enzymatic activities that affect alpha-synuclein degradation and Parkinson's disease susceptibility. - AlzForum Alzheimer Research Paper of the Week


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Home: Papers of the Week

Annotation

	Liu Y, Fallon L, Lashuel HA, Liu Z, Lansbury PT. The UCH-L1 gene encodes two opposing enzymatic activities that affect alpha-synuclein degradation and Parkinson's disease susceptibility. Cell. 2002 Oct 18;111(2):209-18. PubMed Abstract

	Comments on Paper and Primary News

	Comment by: Hiroshi Mori, ARF Advisor
	Submitted 14 November 2002 \| Permalink	Posted 14 November 2002
	I recommend this paper This provides a new insight in protein-degradation study as wellas Parkinson's Disease. It is more interesting how the varations of UCH-L1 affect both activities. View all comments by Hiroshi Mori

	Comment by: John Hardy, ARF Advisor
	Submitted 14 November 2002 \| Permalink	Posted 14 November 2002
	I recommend this paper A very interesting paper: I caution still, however, that a genetic role for UCH-L1 in Parkinson's is not yet established. View all comments by John Hardy

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REAGENTS/MATERIAL:

Antibodies for immunoblotting were monoclonal anti-alpha synuclein 15-123, SYN1 1:2000 (Transduction Labs) and monoclonal anti-ubiquitin from Chemicon at 1:15,000 dilution.

Western blots of synaptic vesicle preparations were probed with anti-UCH-L1 (Chemicon), anti-alpha-synuclein, anti-synaptophysin and anti-synaptotagmin 1 from Transduction Labs.