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Home: Papers of the Week
Annotation


Poorkaj P, Muma NA, Zhukareva V, Cochran EJ, Shannon KM, Hurtig H, Koller WC, Bird TD, Trojanowski JQ, Lee VM, Schellenberg GD. An R5L tau mutation in a subject with a progressive supranuclear palsy phenotype. Ann Neurol. 2002 Oct;52(4):511-6. PubMed Abstract

Comments on Paper and Primary News
  Comment by:  John Hardy, ARF Advisor
Submitted 14 November 2002  |  Permalink Posted 14 November 2002
  I recommend this paper

This mutation is particularly intersting in its position... not near the microtubule binding domains.. and is the second right at the N terminal. This location fits with the notion propounded by Binder, that the N terminal binds to the microtubule binding domains and that this binding is important in determining the kinetics of deposition.

View all comments by John Hardy
  Comment by:  Andre Delacourte
Submitted 14 November 2002  |  Permalink Posted 14 November 2002
  I recommend this paper
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