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Home: Papers of the Week
Annotation


Hartmann D, De Strooper B, Serneels L, Craessaerts K, Herreman A, Annaert W, Umans L, Lübke T, Lena Illert A, Von Figura K, Saftig P. The disintegrin/metalloprotease ADAM 10 is essential for Notch signalling but not for alpha-secretase activity in fibroblasts. Hum Mol Genet. 2002 Oct 1;11(21):2615-24. PubMed Abstract

Comments on Paper and Primary News
  Comment by:  Eddie Koo, ARF Advisor
Submitted 12 October 2002  |  Permalink Posted 12 October 2002
  I recommend this paper

Convincing evidence that ADAM10 is requred for notch S2 cleavage but unclear how it may be involved in APP alpha secretase cleavage. Ultimately, alpha-secretase may indeed be a collection of protease rather than one, could gamma be the same??

View all comments by Eddie Koo
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