Hartmann D, De Strooper B, Serneels L, Craessaerts K, Herreman A, Annaert W, Umans L, Lübke T, Lena Illert A, Von Figura K, Saftig P.
The disintegrin/metalloprotease ADAM 10 is essential for Notch signalling but not for alpha-secretase activity in fibroblasts.Hum Mol Genet.
2002 Oct 1;11(21):2615-24.
Convincing evidence that ADAM10 is requred for notch S2 cleavage but unclear how it may be involved in APP alpha secretase cleavage. Ultimately, alpha-secretase may indeed be a collection of protease rather than one, could gamma be the same??