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| Eat Less, Live More —But Why? Comment by George Perry and Mark A. Smith
Institute of Pathology, Case Western Reserve University, Cleveland, Ohio USA
A well lived life can only be seen in retrospect of a lifetime of living and, in the view of the ancient Greeks, by one of moderation. Scientific support for this view is found in the health benefits of a balanced diet rich in fruits and vegetables ( Lin et al., 2002; Luchsinger et al., 2002) with the greatest health benefit, and increase in longevity, coming from dietary restriction. In this regimen, organisms consuming around 30 percent of calories below ad libum have an approximately 30 to 50 percent increase in lifespan. Decreased free radicals, increased cellular stress, and altered hormonal balance are all thought to play a role but have not been confirmed by mechanistic studies. A link between Alzheimer disease (AD) and caloric intake has been made by case...