|Does estrogen have a future in treating Alzheimer Disease?
Comment by Mary Sano
The Women’s Health Initiative (WHI) has provided startling and disappointing news about hormone replacement therapy (HRT). The authors have thoroughly addressed the issue of cardiovascular disease, osteoporosis and cancers while acknowledging the limitations of this study to answer other questions. For those of us studying Alzheimer’s disease and memory loss this report can help us further define the risks and benefits of a treatment with an unknown role in dementia.
The (WHI) is a 15 -year study, which examines ways to prevent heart disease, breast and colorectal cancer, and osteoporosis. This study did not include dementia or memory loss as a primary outcome measures in its design. Results have recently been reported from over 16,000 women who were taking Prempro, a combination of estrogen and progestin. This large group of post-menopausal women, between the ages of 50 and 79 were followed for a mean of 5.2 years. Findings support an increased risk of breast...