Li YM, Lai MT, Xu M, Huang Q, DiMuzio-Mower J, Sardana MK, Shi XP, Yin KC, Shafer JA, Gardell SJ.
Presenilin 1 is linked with gamma-secretase activity in the detergent solubilized state.Proc Natl Acad Sci U S A.
2000 May 23;97(11):6138-43.
PubMed Abstract, View on AlzSWAN
The large size of the solubilized complex is striking, and suggests that PS1 might act along with many other proteins in a gamma-secretase complex. This is a key step in proving that PS1 is gamma-secretase.