Glial fibrillary acidic protein-apolipoprotein E (apoE) transgenic mice: astrocyte-specific expression and differing biological effects of astrocyte-secreted apoE3 and apoE4 lipoproteins. - AlzForum Alzheimer Research Paper of the Week


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Home: Papers of the Week

Annotation

	Sun Y, Wu S, Bu G, Onifade MK, Patel SN, LaDu MJ, Fagan AM, Holtzman DM. Glial fibrillary acidic protein-apolipoprotein E (apoE) transgenic mice: astrocyte-specific expression and differing biological effects of astrocyte-secreted apoE3 and apoE4 lipoproteins. J Neurosci. 1998 May 1;18(9):3261-72. PubMed Abstract

	Comments on Paper and Primary News

	Comment by: Nikolaos K. Robakis
	Permalink
	This seems a nice paper because it describes a system that can be used to examine any differences in the neurotrophic properties of the various ApoE isoforms. These differences may explain the differential effects of these two proteins in the development of Alzheimer disease neurodegeneration. View all comments by Nikolaos K. Robakis

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