Neuronal DNA damage precedes tangle formation and is associated with up-regulation of nitrotyrosine in Alzheimer's disease brain. - AlzForum Alzheimer Research Paper of the Week


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Annotation

	Su JH, Deng G, Cotman CW. Neuronal DNA damage precedes tangle formation and is associated with up-regulation of nitrotyrosine in Alzheimer's disease brain. Brain Res. 1997 Nov 7;774(1-2):193-9. PubMed Abstract

	Comments on Paper and Primary News

	Comment by: Hiroshi Mori, ARF Advisor
	Permalink
	TUNEL staining is beginning to be popular in AD research. This is the first document to explain the relationship between DNA damage and tangle formation. View all comments by Hiroshi Mori

	Comment by: Paul Coleman, ARF Advisor
	Permalink
	These data are consistent with other data (e.g. from Brad Hyman lab) suggesting that neuron death exceeds the number of NFT. View all comments by Paul Coleman

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