Cholesterol-dependent modulation of tau phosphorylation in cultured neurons. - AlzForum Alzheimer Research Paper of the Week


	Current Papers
	ARF Recommends
	Milestone Papers
	Search All Papers
	Search Comments


	Research News
	Drug News
	Conference News


	AD Hypotheses
		AlzSWAN
		Current Hypotheses
		Hypothesis Factory
	Forums
		Live Discussions
		Virtual Conferences
		Interviews
	Enabling Technologies
		Workshops
		Research Tools
	Compendia
		AlzGene
		AlzRisk
		Antibodies
		Biomarkers
		Mutations
		Protocols
		Research Models
		Video Gallery
	Resources
		Bulletin Boards
		Conference Calendar
		Grants
		Jobs


	Overview
	Diagnosis/Genetics
	Research
	News
	Profiles
	Clinics


	Companies
	Tutorial
	Drugs in Clinical Trials


	About Alzheimer's
		FAQs
	Diagnosis
		Clinical Guidelines
		Tests
		Brain Banks
	Treatment
		Drugs and Therapies
	Caregiving
		Patient Care
		Support Directory
		AD Experiences


	Member Directory
	Researcher Profiles
	Institutes and Labs


	Mission
	ARF Team
	ARF Awards
	Advisory Board
	Sponsors
	Partnerships
	Fan Mail
	Support Us

Home: Papers of the Week

Annotation

	Fan QW, Yu W, Senda T, Yanagisawa K, Michikawa M. Cholesterol-dependent modulation of tau phosphorylation in cultured neurons. J Neurochem. 2001 Jan;76(2):391-400. PubMed Abstract Corresponding Author: Makoto Michikawa

	Comments on Paper and Primary News

	Comment by: Benjamin Wolozin, ARF Advisor (Disclosure)
	Permalink
	I recommend this paper "Increasing data suggests that cholesterol plays an important role in AD. Most studies suggest that lowering cholesterol will protect against AD by reducing Abeta production. However, some studies show that people with low cholesterol are also at risk for dementia. This paper suggests a potential mechanism for this contradictory finding." View all comments by Benjamin Wolozin

Submit a Comment on this Paper

Cast your vote and/or make a comment on this paper.

If you already are a member, please login.
Not sure if you are a member? Search our member database.

*First Name
*Last Name
Country or Territory:
*Login Email Address
*Password	Minimum of 8 characters
*Confirm Password
Stay signed in?

I recommend this paper

Comment:

(If coauthors exist for this comment, please enter their names and email addresses at the end of the comment.)

References:

*Enter the verification code you see in the picture below:

This helps Alzforum prevent automated registrations.

Terms and Conditions of Use:	Printable Version

By clicking on the 'I accept' below, you are agreeing to the Terms and Conditions of Use above.

REAGENTS/MATERIAL:
MAP2 MAb (Sigma) Tau-1 MAb (Boeringer Mannheim) AT-8 MAb (Innogenetics) AT-180 MAb (Innogenetics) PHF-1 MAb (Dr. Peter Davies, Albert Einstein College of Medicine) CP-13 MAb (Dr. Peter Davies, Albert Einstein College of Medicine) Beta-tubulin MAb (Covance) Dilution 1:500 TU-2078, a squalene epoxidase inhibitor (Matzuno et al) Cerebral cortical neuronal culture were prepared from Sprague-Dawley rats.

FUTURE DIRECTION:
Further elucidate the mechanisms of involvement of abnormal cholesterol metabolic alterations in the pathogenesis of NPC. The biochemical requirements for PHF formation in both NPC and AD. Whether cholesterol deficiency and the consequent promotion of tau phosphorylation are involved in the promotion of tau aggregation. Whether there are other factors are involved in the reduction of microtubule stability in axons induced by cholesterol deficiency.

Print this page

Email this page

Alzforum News

Papers of the Week

Text size

Share & Bookmark

Antibodies

Cell Lines

Collaborators

Papers

Research Participants