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Home: Papers of the Week
Annotation


Yu G, Chen F, Nishimura M, Steiner H, Tandon A, Kawarai T, Arawaka S, Supala A, Song YQ, Rogaeva E, Holmes E, Zhang DM, Milman P, Fraser P, Haass C, St George-Hyslop P. Mutation of conserved aspartates affect maturation of presenilin 1 and presenilin 2 complexes. Acta Neurol Scand Suppl. 2000;176:6-11. PubMed Abstract

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  Related Paper: Screening for PS1 mutations in a referral-based series of AD cases: 21 novel mutations.

Comment by:  Hiroshi Mori, ARF Advisor
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  I recommend this paper

This is another peg to establish the role of presenilin molecules in AD, and tells us the significant function lies in the conserved sequence.

View all comments by Hiroshi Mori
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