Degradation of the Alzheimer's amyloid beta peptide by endothelin-converting enzyme. - AlzForum Alzheimer Research Paper of the Week


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Annotation

	Eckman EA, Reed DK, Eckman CB. Degradation of the Alzheimer's amyloid beta peptide by endothelin-converting enzyme. J Biol Chem. 2001 Jul 6;276(27):24540-8. PubMed Abstract Corresponding Author: Christopher B. Eckman

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	Comment by: Benjamin Wolozin, ARF Advisor (Disclosure)
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	I recommend this paper "A novel mechanism for stimulating Abeta aggregation and another potential target for inhibiting Abeta aggregation." View all comments by Benjamin Wolozin

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REAGENTS/MATERIAL:
BAN50/BA27 and BAN50/BC05 antibody systems that detect Ab40 and Ab42, respectively. (Takeda) BNT77 antibody was raised against amino acids 11-29 and recognizes amino terminally modified or truncated peptides of Ab ECE-1a and ECE-1b were cloned by RT-PCR in 2 fragments jointed by a unique Pvu II site ECE-1a forward 5' CAGGAATTCGCCACCATGCCTCTCCCAGGGCCTGGGCCTGC 3' ECE-1b forward 5' CAGGAATTCGCCACCATGCGGGGCGTGTGGCCGCCC 3' ECE-1 Pvu II reverse 5' CAGCAGCTTCCCCAGCTGGACC 3' ECE-1 Pvu II forward 5' GGTCCAGCTGGGGAAGCTGCTG 3' ECE-1 reverse 5' GCTCTAGATTACCAGACTTCGCACTTGTGAGGCGGG 3' Antibody 22C11 antibody that detects secreted APP (Boehringer Manheim)

FUTURE DIRECTION:
Analysis of ECE activity in AD and control individuals is necessary to determine the extent of the involvement of this enzyme family in the development of AD.




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