Peripheral anti-A beta antibody alters CNS and plasma A beta clearance and decreases brain A beta burden in a mouse model of Alzheimer's disease. - AlzForum Alzheimer Research Paper of the Week


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Annotation

	Demattos RB, Bales KR, Cummins DJ, Dodart JC, Paul SM, Holtzman DM. Peripheral anti-A beta antibody alters CNS and plasma A beta clearance and decreases brain A beta burden in a mouse model of Alzheimer's disease. Proc Natl Acad Sci U S A. 2001 Jul 17;98(15):8850-5. PubMed Abstract, View on AlzSWAN

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REAGENTS/MATERIAL:

transgenic PDAPP+/+ mice model and an AD transgenic mouse model with mutant APP transgene were used in this study.

Modified an ELISA into an RIA by using radioactive streptavidin. Antibodies for measurement of amyloid-beta 40 used monoclonal amyloid-beta 40 (m2G3), and amyloid-beta (m266) antibody.