A transcriptionally [correction of transcriptively] active complex of APP with Fe65 and histone acetyltransferase Tip60. - AlzForum Alzheimer Research Paper of the Week


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Home: Papers of the Week

Annotation

	Cao X, Südhof TC. A transcriptionally [correction of transcriptively] active complex of APP with Fe65 and histone acetyltransferase Tip60. Science. 2001 Jul 6;293(5527):115-20. PubMed Abstract, View on AlzSWAN

	Comments on Paper and Primary News

	Comment by: Romulo Meira
	Submitted 14 September 2002 \| Permalink	Posted 14 September 2002
	I recommend this paper

	Comment by: Yungfeng Liao
	Submitted 17 June 2004 \| Permalink	Posted 17 June 2004
	I recommend this paper

	Comment by: Dominic Walsh, ARF Advisor
	Submitted 28 June 2004 \| Permalink	Posted 28 June 2004
	A landmark paper demonstrating that APP intracellular domain is involved in transcriptional regulation. View all comments by Dominic Walsh

	Comment by: shen chengyong
	Submitted 31 August 2004 \| Permalink	Posted 1 September 2004
	I recommend this paper AICD is produced after the γ-secretase proteolysis process. It is similar to NICD as a transcript factor. This paper provides us with the information that APP may function by releasing AICD. Although the target gene of AICD is still unclear, it has been attracting much attention. View all comments by shen chengyong

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REAGENTS/MATERIAL:

HeLa cells transfected with pcDNA3.1-N-HA-Fe65, pCM-VMyc-hTip60 and pCMVS-APP and later stained with monoclonal anti-HA (Babco), rabbit polyclonal anti-APP and goat anti-Myc (Santa Cruz).