This clinical work supports our previous published work suggesting that smaller-sized anesthetics do oligomerize amyloid-β peptide.

References:
Mandal PK, Fodale V. Smaller molecular-sized anaesthetics oligomerize Abeta peptide simulating Alzheimer's disease: a relevant issue. Eur J Anaesthesiol. 2009 Oct;26(10):805-6. Abstract

Mandal PK, Fodale V. Isoflurane and desflurane at clinically relevant concentrations induce amyloid beta-peptide oligomerization: an NMR study. Biochem Biophys Res Commun. 2009 Feb 13;379(3):716-20. Abstract

Fodale V, Ritchie K, Rasmussen LS, Mandal PK. Anesthetics and Alzheimer's disease: background and research. Preface. J Alzheimers Dis. 2010;22 Suppl 3:1-3. Abstract

Mandal PK, Bhavesh NS, Chauhan VS, Fodale V. NMR investigations of amyloid-β peptide interactions with propofol at clinically relevant concentrations with and without aqueous halothane solution. J Alzheimers Dis. 2010;21(4):1303-9. Abstract

Mandal PK, Simplaceanu V, Fodale V. Intravenous anesthetic diazepam does not induce amyloid-beta peptide oligomerization but diazepam co-administered with halothane oligomerizes amyloid-beta peptide: an NMR study. J Alzheimers Dis. 2010;20(1):127-34. Abstract

Mandal PK, Schifilliti D, Mafrica F, Fodale V. Inhaled anesthesia and cognitive performance. Drugs Today (Barc). 2009 Jan;45(1):47-54. Abstract

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