Coordination between proteasome impairment and caspase activation leading to TAU pathology: neuroprotection by cAMP. - AlzForum Alzheimer Research Paper of the Week


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Annotation

	Metcalfe MJ, Huang Q, Figueiredo-Pereira ME. Coordination between proteasome impairment and caspase activation leading to TAU pathology: neuroprotection by cAMP. Cell Death Dis. 2012;3:e326. PubMed Abstract

	Comments on Paper and Primary News

	Comment by: Nikolaos K. Robakis
	Submitted 10 July 2012 \| Permalink	Posted 11 July 2012
	I recommend this paper This is a very interesting work, showing for the first time that increasing neuronal cAMP prevents caspase activation, tau cleavage, and neuronal cell death. The data in the paper support the suggestion that increasing proteasome activity in a sustainable manner may offer an effective way to block caspase activation and tau cleavage, possibly preventing or delaying AD neurodegeneration. View all comments by Nikolaos K. Robakis

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