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Home: Papers of the Week
Annotation


Vassar R, Bennett BD, Babu-Khan S, Kahn S, Mendiaz EA, Denis P, Teplow DB, Ross S, Amarante P, Loeloff R, Luo Y, Fisher S, Fuller J, Edenson S, Lile J, Jarosinski MA, Biere AL, Curran E, Burgess T, Louis JC, Collins F, Treanor J, Rogers G, Citron M. Beta-secretase cleavage of Alzheimer's amyloid precursor protein by the transmembrane aspartic protease BACE. Science. 1999 Oct 22;286(5440):735-41. PubMed Abstract, View on AlzSWAN

  
Comments on Related Papers
  Related Paper: Mice deficient in BACE1, the Alzheimer's beta-secretase, have normal phenotype and abolished beta-amyloid generation.

Comment by:  John Hardy, ARF Advisor
Permalink
  I recommend this paper

"An excellent paper, not only establishing BACE as b -secretase but also suggesting that knockout (or, by implication drug inhibition) may not have major adverse effects."

View all comments by John Hardy
  Related Paper: Mice deficient in BACE1, the Alzheimer's beta-secretase, have normal phenotype and abolished beta-amyloid generation.

Comment by:  Yungfeng Liao
Submitted 17 June 2004  |  Permalink Posted 17 June 2004
  I recommend this paper
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Presenting...β-Secretase

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Mice deficient in BACE1, the Alzheimer's beta-secretase, have normal phenotype and abolished beta-amyloid generation.
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