This is a thorough paper showing that CSF levels of VILIP-1 carry similar information as total tau. High CSF levels of the protein indicate intense neurodegeneration, which translates into rapid disease progression and cognitive decline. Whereas the information may be similar, it is important to have alternative biomarkers in the AD field. Much effort has lately been directed to biomarker standardization, and from that perspective, total tau assays may be difficult to standardize, given the many isoforms and modifications of the protein. With some luck VILIP-1 might be easier.

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