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Home: Papers of the Week
Annotation


Greenfield JP, Tsai J, Gouras GK, Hai B, Thinakaran G, Checler F, Sisodia SS, Greengard P, Xu H. Endoplasmic reticulum and trans-Golgi network generate distinct populations of Alzheimer beta-amyloid peptides. Proc Natl Acad Sci U S A. 1999 Jan 19;96(2):742-7. PubMed Abstract

Comments on Paper and Primary News
  Comment by:  Hiroshi Mori, ARF Advisor
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Two amyloid species (Abeta40 and Abeta42/43) are enerated at TGN and ER, respectively. The question is how they change to an insoluble form in brain tissue in an age-dependent and pathological manner.

View all comments by Hiroshi Mori
Comments on Related Papers
  Related Paper: The transmembrane domain of the Alzheimer's beta-secretase (BACE1) determines its late Golgi localization and access to beta -amyloid precursor protein (APP) substrate.

Comment by:  Hiroshi Mori, ARF Advisor
Permalink
  I recommend this paper

"This presents a crucial result on the localization and function for BACE but the question remains open whether all of APP is not digested by BACE in distal Golgi membrane, ER, endosome or plasma membrane."

View all comments by Hiroshi Mori
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The transmembrane domain of the Alzheimer's beta-secretase (BACE1) determines its late Golgi localization and access to beta -amyloid precursor protein (APP) substrate.
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