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Home: Papers of the Week
Annotation


Guo Q, Fu W, Sopher BL, Miller MW, Ware CB, Martin GM, Mattson MP. Increased vulnerability of hippocampal neurons to excitotoxic necrosis in presenilin-1 mutant knock-in mice. Nat Med. 1999 Jan;5(1):101-6. PubMed Abstract, View on AlzSWAN

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  Comment by:  Hiroshi Mori, ARF Advisor
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It is worth to note the normal physiological level of exogenous human PS1 variant in mouse. The data suggest excitotoxic necrosis rather than apoptosis.

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