Mutation in the alpha-synuclein gene and sporadic Parkinson's disease, Alzheimer's disease, and dementia with lewy bodies. - AlzForum Alzheimer Research Paper of the Week

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Home: Papers of the Week

Annotation

	Higuchi S, Arai H, Matsushita S, Matsui T, Kimpara T, Takeda A, Shirakura K. Mutation in the alpha-synuclein gene and sporadic Parkinson's disease, Alzheimer's disease, and dementia with lewy bodies. Exp Neurol. 1998 Sep;153(1):164-6. PubMed Abstract

	Comments on Paper and Primary News

	Comment by: Paul Coleman, ARF Advisor
	Permalink
	'Exploration of the ... mutation of the alpha-synuclein gene as that in familial PD (Ala53Thr) ... in sporadic PD, DLB, and AD revealed the mutation in none of the samples of 329 cases and 230 controls examined, suggesting that this mutation is not involved in these neurological diseases.' View all comments by Paul Coleman

	Comments on Related Papers

	Related Paper: Alpha-synuclein-positive structures in cases with sporadic Alzheimer's disease: morphology and its relationship to tau aggregation. Comment by: Benjamin Wolozin, ARF Advisor (Disclosure)
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	I recommend this paper "Our understanding of a-synuclein pathology is limited and increasing daily. This suggests further subdivisions within AD." View all comments by Benjamin Wolozin

	Related Paper: Immunohistochemical distribution of the receptor for advanced glycation end products in neurons and astrocytes in Alzheimer's disease. Comment by: Benjamin Wolozin, ARF Advisor (Disclosure)
	Permalink
	I recommend this paper "Our understanding of a-synuclein pathology is limited and increasing daily. This suggests further subdivisions within AD." View all comments by Benjamin Wolozin

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