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Home: Papers of the Week
Annotation


Lambert JC, Berr C, Pasquier F, Delacourte A, Frigard B, Cottel D, Pérez-Tur J, Mouroux V, Mohr M, Cécyre D, Galasko D, Lendon C, Poirier J, Hardy J, Mann D, Amouyel P, Chartier-Harlin MC. Pronounced impact of Th1/E47cs mutation compared with -491 AT mutation on neural APOE gene expression and risk of developing Alzheimer's disease. Hum Mol Genet. 1998 Sep;7(9):1511-6. PubMed Abstract, View on AlzGene

Comments on Related Papers
  Related Paper: The -48 C/T polymorphism in the presenilin 1 promoter is associated with an increased risk of developing Alzheimer's disease and an increased Abeta load in brain.

Comment by:  Alison Goate, ARF Advisor
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  I recommend this paper

"Interesting paper showing an association between risk for AD and a polymorphism in the promoter of PS1. The risk genotype is also associated with increased Ab load in the brain. These observations are consistent with the hypothesis that increased PS1 expression leads to increased g-secretase activity and thus increased Ab levels."

View all comments by Alison Goate
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The -48 C/T polymorphism in the presenilin 1 promoter is associated with an increased risk of developing Alzheimer's disease and an increased Abeta load in brain.
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