Presenilin 1 associates with glycogen synthase kinase-3beta and its substrate tau. - AlzForum Alzheimer Research Paper of the Week


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Home: Papers of the Week

Annotation

	Takashima A, Murayama M, Murayama O, Kohno T, Honda T, Yasutake K, Nihonmatsu N, Mercken M, Yamaguchi H, Sugihara S, Wolozin B. Presenilin 1 associates with glycogen synthase kinase-3beta and its substrate tau. Proc Natl Acad Sci U S A. 1998 Aug 4;95(16):9637-41. PubMed Abstract, View on AlzSWAN

	Comments on Paper and Primary News

	Comment by: Hiroshi Mori, ARF Advisor
	Permalink
	GSK-3 is proposed to be located at the upstream of pathology from the binding of presenilin-1. The total cascade will go to more complex but interesting issue. View all comments by Hiroshi Mori

	Comment by: Paul Coleman, ARF Advisor
	Permalink
	This ability of PS 1 to link GSK-3-beta with tau may be particularly important in view of the role that GSK-3-beta appears to play in phosphorylating tau. View all comments by Paul Coleman

	Comments on Related Papers

	Related Paper: Decreased nuclear beta-catenin, tau hyperphosphorylation and neurodegeneration in GSK-3beta conditional transgenic mice. Comment by: Benjamin Wolozin, ARF Advisor (Disclosure)
	Permalink
	I recommend this paper "This paper provides in vivo support for a putative role of GSK in the regulation of catenin and tau phosphorylation." View all comments by Benjamin Wolozin

	Related Paper: Decreased nuclear beta-catenin, tau hyperphosphorylation and neurodegeneration in GSK-3beta conditional transgenic mice. Comment by: Eddie Koo, ARF Advisor
	Permalink
	I recommend this paper "Good in vivo experimental evidence of GSK phosphorylating tau. Previously, most brain evidence has been correlative." View all comments by Eddie Koo

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