These are not the only Alzheimer's disease-related genes that are implicated in the viral life cycle. Others are catalogued at Polygenic Signaling Pathways
, and there is also a database of Herpes simplex host viral interactions
It is worth pointing out that Herpes simplex infection in mice produces entorhinal and hippocampal cell loss, cerebral shrinkage, and memory deficits (Armien et al., 2010). The lesions are not exactly those seen in Alzheimer's disease, (nor are those from the various APP transgenic models) but they show that viral infection can produce many of its features. Ruth Itzhaki's group has also shown that viral infection produces β amyloid deposition and increases tau phosphorylation.
Two years ago, a retrospective analysis showed that HSV-1 seropositivity, of the type indicating viral reactivation, was a reliable predictor of the subsequent development of Alzheimer's disease (Letenneur et al.,...