Amyloid-beta deposition in Alzheimer transgenic mice is associated with oxidative stress. - AlzForum Alzheimer Research Paper of the Week


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Annotation

	Smith MA, Hirai K, Hsiao K, Pappolla MA, Harris PL, Siedlak SL, Tabaton M, Perry G. Amyloid-beta deposition in Alzheimer transgenic mice is associated with oxidative stress. J Neurochem. 1998 May;70(5):2212-5. PubMed Abstract

	Comments on Paper and Primary News

	Comment by: John Olney, ARF Advisor
	Permalink
	Smith et al study the relationship between oxidative stress and amyloid-beta deposition in the brains of transgenic mice. They find that markers for oxidative stress co-localize with amyloid deposits in the transgenic mouse brains. Significance of the findings in relation to AD is limited in that no link is developed between either amyloid or oxidative stress and neuronal degeneration in AD. View all comments by John Olney

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