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Home: Papers of the Week
Annotation


Qian S, Jiang P, Guan XM, Singh G, Trumbauer ME, Yu H, Chen HY, Van de Ploeg LH, Zheng H. Mutant human presenilin 1 protects presenilin 1 null mouse against embryonic lethality and elevates Abeta1-42/43 expression. Neuron. 1998 Mar;20(3):611-7. PubMed Abstract, View on AlzSWAN

Comments on Paper and Primary News
  Comment by:  Hiroshi Mori, ARF Advisor
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This is extremely an important paper. Axial skeleton malformation and CNS defects in PS1-null mice is rescued by both wild and mutated PS1. It indicates that PS1 plays at least two roles involved in axial skeletal formation and amyloid formation.

View all comments by Hiroshi Mori
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