|Time for the Ubiquitin-Proteasome System #3
These papers look very interesting and show the relevance in Alzheimer disease of an efficient working protein quality control by the ubiquitin-proteasome system (UPS) and by autophagy, two systems that show crosstalk. I am organizing a satellite on this subject soon at a FENS meeting
The papers agree with the idea that an efficient working UPS is very relevant for preventing and/or delaying AD; see our recent mini-review in Neurodegenerative Diseases (Dennissen et al., 2010). These two papers add again pieces of the puzzle to aid in dissecting AD pathogenesis, particularly the Halawani paper in MCI (see also my two previous comments Time for the ubiquitin-proteasome system and Time for the...