Accelerated Alzheimer-type phenotype in transgenic mice carrying both mutant amyloid precursor protein and presenilin 1 transgenes. - AlzForum Alzheimer Research Paper of the Week


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Home: Papers of the Week

Annotation

	Holcomb L, Gordon MN, McGowan E, Yu X, Benkovic S, Jantzen P, Wright K, Saad I, Mueller R, Morgan D, Sanders S, Zehr C, O'Campo K, Hardy J, Prada CM, Eckman C, Younkin S, Hsiao K, Duff K. Accelerated Alzheimer-type phenotype in transgenic mice carrying both mutant amyloid precursor protein and presenilin 1 transgenes. Nat Med. 1998 Jan;4(1):97-100. PubMed Abstract

	Comments on Paper and Primary News

	Comment by: Hiroshi Mori, ARF Advisor
	Permalink
	Undoubtedly this paper indicates an AD model to show neuropathological change and enables us to analyze the detailed study. It is important to be aware that the behavioral change appears before neuropathological changes such as the plaque formation. View all comments by Hiroshi Mori

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