In the January JAMA Neurology, researchers formally published the results of the Phase 3 trial of Dimebon®, aka latrepirdine, in Huntington’s disease patients. In April 2011, the drug’s sponsors, Medivation Inc. and Pfizer, announced that Dimebon failed to show efficacy in the six-month HORIZON trial, which enrolled 403 people with Huntington’s disease in 11 countries (see ARF related news story). The drug had shown hints of cognitive benefit in a Phase 2 trial (see ARF related news story), but in Phase 3, people taking Dimebon showed no improvement over controls on the Mini-Mental State Examination or the Clinician Interview-Based Impression of Change. The Huntington Study Group and the European Huntington’s Disease Network carried out the trial.
The findings echo Dimebon's tribulations in Alzheimer’s disease, where promising Phase 2 results (see ARF related news story) evaporated in Phase 3 (see ARF related news story; ARF news story).—Madolyn Bowman Rogers
- No Effect Seen in Huntington’s Disease Trial of Dimebon
- Dimebon for HD—A Hint of Cognitive Benefit?
- Boston: Clinical Trial Results for Dimebon Unveiled
- Dimebon Disappoints in Phase 3 Trial
- CONCERT Trial of Dimebon Falls Flat
- A Randomized, Double-blind, Placebo-Controlled Study of Latrepirdine in Patients With Mild to Moderate Huntington Disease. Arch Neurol. 2012 Oct 1;:1-9. PubMed.