A trio of articles will appear in tomorrow's issue of Nature, reporting that Aβ peptide immunization reduces a memory deficit in transgenic mouse models of AD. The findings from the University of Toronto and University of South Florida were reported earlier this year at scientific meetings (covered by this news forum). One of the Toronto coauthors, David Westaway, cautions: ``There is a complication still-the relationship between plaque and learning and memory might not be a straight-line one. But I think this does give us cause for optimism. We could have done this and come away with nothing.''—Hakon Heimer
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- Morgan D, Diamond DM, Gottschall PE, Ugen KE, Dickey C, Hardy J, Duff K, Jantzen P, DiCarlo G, Wilcock D, Connor K, Hatcher J, Hope C, Gordon M, Arendash GW. A beta peptide vaccination prevents memory loss in an animal model of Alzheimer's disease. Nature. 2000 Dec 21-28;408(6815):982-5. PubMed.
- Chapman PF. Alzheimer's disease: model behaviour. Nature. 2000 Dec 21-28;408(6815):915-6. PubMed.