Kawarabayashi (319.10) presented compelling data for a time-dependent accumulation of Aβ in the detergent-insoluble glycolipid enriched membrane domains (DIGs) of Tg2576 mouse brain. He also showed that Aβ accumulated in DIGs from human brain and the extent of accumulation was greater in AD brain than in matched controls. These data suggest that Aβ accumulation in DIGs maybe a harbinger of amyloid fibril formation and lend further support to the thesis that membrane environments plays a central role in both the generation and aggregation of Aβ.

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