Are you intrigued by the rapidly unfolding progress of basic RNAi research? Do you wonder how early attempts to develop therapeutics out of this field are shaping up, and where the technical barriers lie? If so, you might enjoy an online summary of a Nature/Aventis Horizon Symposium held last month in Maine. The Web site features background material on ribozymes, microRNAs, the spliceosome, and RNA-based therapeutic strategies, as well as articles, written both at an expert and at a lay level, that summarize the symposium’s six sessions. For Alzforum coverage of RNAi in neurodegenerative disease, see Live Discussion.-Gabrielle Strobel.