Monteiro and Janicki et al. (Abstract 1057) showed by BrdU labeling of HeLa cells that overexpression of both PS1 and PS2 arrest cells in the G1 phase of the cell cycle. This arrest presumably precedes apoptosis of the cells which this group has reported in an earlier publication. The mechanisms by which presenilin induces cell cycle arrest was not revealed, as simple changes in protein levels of cell cycle regulators such as, p53, p21, p27, or myc were not seen.—June Kinoshita

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