Harada et al. (Abstract 902) have now disrupted the MAP2 gene in mouse. Like tau and MAP1B knockout mice, MAP-2 knockout mice are fertile and have apparently normal brain cytoarchitecture. Interestingly, double tau and MAP1B knockout mice (Abstract 2284) die before they are four weeks old and show abnormalities of brain structures, particularly the corpus callosum, indicating that redundant functions between MAPS may not be compensated when two or more MAP genes are disrupted.—June Kinoshita


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