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1 to 25 of 491 results

Copper Mountain: Death and Trophin Receptors—New Insight, New Drugs?
3 February 2010. Death and taxes are reputedly inevitable, though death and receptors may be more interesting to Alzforum readers...

Copper Mountain Brief: Rat-a-tat—New Model Comes a Knockin’
1 February 2010. Bigger, smarter, and more amenable than mice to the imaging techniques that are rapidly becoming indispensable in AD research, rats could be a valuable model for studying AD...

Copper Mountain: Knight Vision—SIRT1 Aids ADAM10, Slays Aβ
1 February 2010. Gizem Donmez reported that SIRT1 might protect against AD by boosting ADAM10 (aka α-secretase) and promoting non-amyloidogenic processing of Aβ APP...

Copper Mountain: Can CREB Save Memory?
25 January 2010. The Keystone Symposium at Copper Mountain, Colorado, was convened to discuss therapeutic approaches to Alzheimer disease besides those that target amyloid-β...

Chicago: Fanning the Flames of PyroGluAβ in Academia
9 December 2009. Exactly which form the amino end of Aβ takes in the brains of people with AD is a question that increasingly crops up in talks about immunotherapy and even other dementias...

Chicago: Interest in PyroGluAβ Flares Up in Academia
9 December 2009. Pyroglutamate Aβ has been making a return to center stage in AD research after languishing in relative obscurity for a decade following its initial discovery...

Las Vegas: 2020 Vision—AD Prevention in 11 Years?
8 December 2009. Could foresight be 2020 for Alzheimer disease? Zaven Khachaturian has proposed a national strategic plan of preventing the disease within 11 years...

Chicago: NFATs, Calcineurin—Mediators of AD, PD Pathogenesis?
2 December 2009. Several posters beefed up the concept that signaling via calcineurin and NFATs may play a central role in neurodegenerative disease pathogenesis...

Las Vegas: Prevention Prominent at CTAD
22 November 2009. At the second annual Clinical Trials on Alzheimer’s Disease meeting, prevention—how, when, with what interventions—dominated the discussions...

Chicago: The Vampire Principle—Young Blood Rejuvenates Aging Brain?
20 November 2009. Scientists at last month’s Society for Neuroscience conference in Chicago confirmed the vampire principle, whereby young blood keeps an aging organism vigorous...

Paper Alert-cum-SfN: Bapineuzumab Published, More AN1792 Presented
19 November 2009. Phase 2 clinical trial data for bapineuzumab, Elan/Wyeth’s humanized monoclonal antibody against amyloid-β, were published...

Chicago: New Technologies Help Drugs Cross Blood-Brain Barrier
15 November 2009. Designing compounds to fight neurodegenerative disease comes with the additional challenge of making sure they actually reach the brain...

Las Vegas: AD, Risk, ApoE—Tomm40 No Tomfoolery
15 November 2009. Though the ApoE4 variant is the strongest genetic risk factor for late-onset Alzheimer disease, it offers no definitive test...

Chicago: AD and Epilepsy—Lessons from the Clinic, Animals
13 November 2009. The SfN annual meeting featured a rare convergence of epilepsy and Alzheimer disease researchers at a symposium focused on shared features of these two disorders...

Chicago: AD and Epilepsy—Joined at the Synapse?
13 November 2009. In the past two years, a closer look at epilepsy and Alzheimer disease has revealed some fundamental similarities...

Las Vegas: New Partner, New Game Plan for Lou Ruvo Brain Institute
7 November 2009. Relationships forged amidst the glitz and glamour of Las Vegas have a reputation for ending badly; the one between the University of Nevada, Reno (UNR), and the Lou Ruvo Brain Institute (LRBI) was apparently no exception...

Chicago: Nicotinic AChRs—Mechanistic Basis for New Drug Discovery?
7 November 2009. It’s refreshing to hear about studies showing clear convergence between biology, drug action, and behavior, all in the space of a few seconds, no less...

Chicago: Move Over, Agonists; Make Way for Modulators
6 November 2009. At a satellite symposium, “Nicotinic Acetylcholine Receptors (nAChRs) as Therapeutic Targets,” clinical discussion of cognitive treatments focused largely on nAChR agonists...

Chicago: Nicotinic AChRs: α4β2 Iffy for AD, More Promise With α7?
5 November 2009. Days before the masses swarmed to the SfN annual meeting, a more intimate assembly of 287 exchanged the latest buzz on nicotinic acetylcholine receptors...

Chicago: Tau and α-Synuclein Oligomers Follow Aβ Footsteps
5 November 2009. In Alzheimer disease research, focus has recently shifted away from large plaques and toward small oligomers of amyloid as a potential cause of disease...

Chicago: Axonal Transport Not So Fast in Neurodegenerative Disease
3 November 2009. The long axons of neurons act as intracellular highways, with motor proteins shuttling their cargo up and down microtubule tracks...

St. Louis: An eFAD Prevention Trial—One Man’s View
1 November 2009. DIAN was founded with the hope that its participating families could be offered a prevention trial and/or treatment trial before too long...

St. Louis: Imaging Preclinical AD—Can You See it Coming in the Brain?
30 October 2009. At the 7th Leonard Berg Symposium, brain imaging researchers of various stripes took stock of what brain imaging tells the field about the preclinical period of Alzheimer disease...

St. Louis: Is Rare Familial Alzheimer’s a Model for the Millions?
28 October 2009. One question that pervaded the 7th Leonard Berg Symposium is whether dominantly inherited Alzheimer disease really is the same disease as the common late-onset forms...

St. Louis: Biomarkers Pre-dementia—Like eFAD, Like LOAD?
27 October 2009. As throughout this conference, talks toggled between what’s known in LOAD and eFAD, comparing all the while how well knowledge on these forms of AD matches up...

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