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HAI—Aβ: First in Alzheimer’s Cascade, or Just Another Player?
6  February 2013. Scientists worldwide now perform amyloid imaging on scores of research participants to figure out how Aβ buildup relates to other markers of neurodegeneration...

  
HAI—Standardizing Amyloid PET: The Centiloid Project
1  February 2013. A centiloid is a proposed unit of measure on a unified scale for all amyloid-β imaging tracers used in positron emission tomography (PET)...

  
HAI—Sharper Curves: Revamping a Biomarker Staging Model
1  February 2013. Clifford Jack's hypothetical model showing biomarkers emerging at different stages of AD surged to the top of the Most-Popular-Slide-at-Conferences chart...

  
HAI—Amyloid Imaging in the Clinic: New Guidelines and Data
29  January 2013. Since the FDA approved the Aβ imaging agent florbetapir (Amyvid®) last April, academics and doctors have debated how it should be used...

  
HAI—Spotlight on Tau Tracers at Human Amyloid Imaging Meeting
25  January 2013. A group of 250 scientists met at the 7th Human Amyloid Imaging (HAI) meeting to share the most up-to-date research on brain imaging...

  
NIH Funds Four Clinical Trials in ADCS Renewal
18  January 2013. The National Institutes of Health announced that it will fund the Alzheimer’s Disease Cooperative Study to conduct four new clinical studies over the next five years...

  
Solanezumab Selected for Alzheimer’s A4 Prevention Trial
18  January 2013. Researchers announced the selection of solanezumab as the first therapeutic drug to be evaluated in the A4 prevention clinical trial...

  
Chicago—RNA Inclusions Offer Therapeutic Target in ALS
11  January 2013. ALS researchers were excited to hear progress reports from two separate collaborations pursuing antisense oligonucleotide therapy...

  
Chicago—Dynamic Repeats: C9ORF72 Expands and Shrinks in ALS
11  January 2013. For years, scientists hunted for the mutation on chromosome 9 that causes ALS, and the subsequent discovery of the mysterious C9ORF72 was hardly the end of the challenge...

  
Zuers—Can Spatial Navigation Guide Clinical Trials?
9  January 2013. What if prodromal AD patients could be tested before and after treatment in a human version of the Morris water maze?...

  
Chicago—Devilish Duo: Two Mutations Add Up to Familial ALS
9  January 2013. As if the genetic basis for amyotrophic lateral sclerosis was not complicated enough, attendees at the International Symposium on ALS/MND heard another wrinkle to the story...

  
Zuers—No Pill or Drip: Scientists Inject Phage Drug Into CSF
8  January 2013. The meeting featured alternative treatment approaches that are trying to reach the starting line for clinical trials...

  
Zuers—Αlpha, Beta, Sigma: Which Will Yield New AD Drug?
7  January 2013. New targets and compounds with which to hit them took up much space on the program...

  
Chicago—ALS Clinical Trials: New Hope After Phase 3 Setbacks
4  January 2013. Researchers, therapists, patients, and caretakers came together in Chicago, Illinois, to share a common goal of finding a cure for ALS...

  
Zuers—Meeting Mixes Translational News and Debate
4  January 2013. In a snowy mountain town in Austria, 75 scientists traded data and discussion of AD treatment approaches...

  
Chicago—ALS Protein SOD1 Painted as Disease Template
29  December 2012. At the 23rd annual International Symposium on ALS/MND, genetics was, as ever, a hot topic...

  
Chicago—ALS Database Opens for Business
7  December 2012. Data miners: Start your search engines...

  
SfN: Tau Toxicity in the Limelight
30  November 2012. A growing number of studies stress the harmful effects of tau in AD, but exactly how the protein exerts toxicity, and how it interacts with Aβ, remain open to question...

  
CTE Advocates Pivot Toward Preventing Concussions in Kids
28  November 2012. When a medical examiner reported CTE in former football players who had died young, the specter of neurodegeneration in concussed athletes quickly gained momentum...

  
CTE Needs Consensus on Lifetime Diagnosis
27  November 2012. When a new disease emerges, clinicians grapple early on with how to diagnose it...

  
Do Tau "Prions" Lead the Way From Concussions to Progression?
26  November 2012. A growing number of researchers view age-related neurodegenerative diseases as being due to pathogenic alter egos of otherwise normal proteins...

  
CTE: Trauma Triggers Tauopathy Progression
23  November 2012. What exactly goes on in the brains of people when blows to the head turn into a degenerative tau disease months or even years after the trauma...

  
SfN: Epigenetic Changes in Alzheimer’s and Cognitive Decline
21  November 2012. At SfN, researchers pored over epigenetic marks predisposing to AD and cognitive decline, and discussed how those might be targeted therapeutically...

  
CTAD: AD Treatment Might Not Lower Healthcare Costs
21  November 2012. Researchers modeled a hypothetical disease-modifying AD treatment and found that the expense of the drug could more than offset the money saved in nursing home care...

  
Boxing: Study of Human Model for CTE Enters Second Round
21  November 2012. Professional boxing offers a unique opportunity to study the natural history of CTE for an understanding of its presymptomatic pathogenesis and progression...

  
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PIB PET in early AD patient reveals amyloid in cortex and deep brain areas.[Video courtesy of Scott Ziolko and the Pittsburgh Amyloid Imaging Group]
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