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Lilly Halts IDENTITY Trials as Patients Worsen on Secretase Inhibitor
18
August 2010.
Eli Lilly and Company announced yesterday that it has halted its Semagacestat γ-secretase inhibitor program...
Anti-Aβ Oligomer Headed for Phase 3 Clinical Trial
13
August 2010.
Top-line data announced this week from a Phase 2 clinical trial of the drug scyllo-inositol give cause to move to Phase 3...
Research Brief: Lithium for ALS—Another Nail in the Coffin?
13
August 2010.
Yet again, lithium has failed to live up to its promise in the treatment of amyotrophic lateral sclerosis...
Drugs, Old and New, Offer Glimmer of Hope for Huntington’s
14
May 2010.
There may be a new glimmer of hope for patients with Huntington disease (HD)...
Paper Alert: Lithium for ALS Deemed Futile, Study Stops Early
7
April 2010.
Mounting scientific evidence continues to dash once-high hopes that lithium can help people with amyotrophic lateral sclerosis...
Research Brief: Medivation Scales Back
1
April 2010.
Following disappointing results in its Phase 3 CONNECTION trial of Dimebon for Alzheimer disease (AD), Medivation, Inc., is cutting its workforce...
Dimebon Disappoints in Phase 3 Trial
4
March 2010.
One swallow does not make a summer, and one positive clinical trial does not make an Alzheimer’s drug...
Dimebon for HD—A Hint of Cognitive Benefit?
12
February 2010.
The results of the first U.S. Phase 2 trial for Dimebon in Huntington disease are finally out in print...
Clinical Trials for ALS: Taking Stock of 2009, Looking to 2010
15
January 2010.
The Alzforum presents a selection of some of the top ALS trial news of 2009—and looks ahead to 2010 and beyond...
Drug Brief: Generic Aricept Approval—Melts in Your Mouth?
22
December 2009.
On 11 December 2009, the U.S. Food and Drug Administration (FDA) announced approval of a generic version of Aricept...
Paper Alert—Phase 3 Tarenflurbil Data Published
17
December 2009.
Tarenflurbil, aka flurizan, a γ-secretase modulator that showed promise in early preclinical and clinical trials, failed in Phase 3...
Drug Brief—Adverse Events Prompt Dose Drop in Elan Trial
16
December 2009.
It appears that Dublin-based Elan's small molecule drug candidate ELND005 has run into some trouble...
Paper Alert-cum-SfN: Bapineuzumab Published, More AN1792 Presented
19
November 2009.
Phase 2 clinical trial data for bapineuzumab, Elan/Wyeth’s humanized monoclonal antibody against amyloid-β, were published...
Research Brief: Glatiramer Slows Progression From High Risk to MS
15
October 2009.
A drug used to prevent relapse of multiple sclerosis can also prevent people at risk from developing the full disease, according to a report by The Lancet...
Medical Foods—Food for Thought, But Think Twice
15
October 2009.
While the AD field awaits a bona fide drug that goes beyond temporary relief of symptoms, patients may be increasingly open to products claiming even the slightest hint of promise...
Dimebon: Bright Star or Black Hole?
14
October 2009.
Dimebon appears as one bright light in a field of less-than-stellar clinical trial results of late...
Medical Foods—Fallback Option for Elusive AD Drug Status?
14
October 2009.
Defined by the FDA in 1988, medical foods are a special class of therapeutic agent that fall somewhere in between unregulated food supplements and FDA-approved drugs...
Vienna: New Shoot Among Ashes of Drug Trials
29
July 2009.
At the ICAD, news on the drug trials landscape painted a mostly bleak picture, but of course, that’s not the whole story...
NO Joke: Viagra Lessens Aβ, Cognitive Problems in AD Mice
26
June 2009.
Giving Alzheimer mice a three-week regimen of Viagra (sildenafil) sharpens their memories and lessens the load of amyloid-β (Aβ) in their brains...
News Brief: What’s Up With Iplex?
22
May 2009.
The efficacy of Iplex is unknown; it is untested in clinical trials, untried in mouse models, and, for the most part, unapproved by the Food and Drug Administration...
Drug News Brief: Bapineuzumap Trial Drops Highest Dose
2
April 2009.
Elan and Wyeth announced today that two ongoing Phase 3 clinical trials of Bapineuzumab will discontinue the highest planned dose of 2 mg/kg...
Antipsychotics on Trial Again—DART-AD Confirms Increased Mortality
9
January 2009.
Antipsychotics are getting pushback as a treatment for behavioral symptoms in AD patients...
IGF-1 Disappoints in Trials for AD, ALS
19
December 2008.
November was a dreary month for those who had high hopes for insulin-like growth factor-1 as a treatment for neurodegenerative disorders...
Big Ginkgo Prevention Trial Comes Up Negative
22
November 2008.
Older people who are buying and taking ginkgo biloba pills to ward off Alzheimer disease can save their money...
Experts Slam Marketing of Tramiprosate (Alzhemed) as Nutraceutical
10
October 2008.
The Canadian pharmaceutical company Bellus Health has begun to sell the would-be prescription drug tramiprosate over the counter as a nutritional supplement...