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1 to 25 of 3392 results
Immune Cell Receptor Gives Aβ a Toxic Edge
18  June 2013. Despite ample evidence implicating Aβ in Alzheimer’s pathology, scientists still struggle to understand how the peptide harms the brain.

  
Lilly Halts Phase 2 Trial of BACE Inhibitor Due to Liver Toxicity
14  June 2013. Eli Lilly and Company announced yesterday that they have terminated the Phase 2 trial of their BACE inhibitor LY2886721 due to liver abnormalities.

  
In Familial AD, Aβ Production Up, Clearance Down
14  June 2013. Researchers have long assumed that people with familial Alzheimer’s disease make too much Aβ42 in the brain, but they lacked proof.

  
Prevalence of Dementia, AD, in China Eclipses Predictions
14  June 2013. A report on global disease burden found that the number of deaths in China due to Alzheimer’s disease and other dementias doubled between 1990 and 2010.

  
DSM-5: Debated? Yes. Important for AD Diagnosis? Maybe Not
13  June 2013. After more than a decade in the works, the long-awaited fifth edition of the Diagnostic and Statistical Manual of Mental Disorders (DSM-5) arrived last month to little fanfare.

  
Do Biomarkers Improve Diagnostic Accuracy?
13  June 2013. It’s a scenario familiar to many clinicians: A patient diagnosed with mild cognitive impairment asks if he or she will eventually develop Alzheimer’s disease.

  
Building a Roadmap for Shared Combination Drug Trials
13  June 2013. As potential AD drugs continue to post disappointing Phase 2/3 results, many in the field are considering upping the artillery by testing experimental drugs in combination.

  
Genotype-Based Meta-Analysis Suggests Serum Iron Protects Against PD
11  June 2013. Though iron gets a bad rap for accumulating in the brains of older people and individuals with neurodegenerative disease, could an abundance of this metal in the blood bode well?

  
Mouse Brain Circulatory System Knows No Bounds
9  June 2013. Tiny blood vessels in the mouse brain crisscross the cortex, passing from one neural column to the next, like multiple streets between interconnecting city blocks...

  
Satori Pharmaceuticals Shuts Down, Abandons γ-Secretase Modulators
7  June 2013. Satori Pharmaceuticals, which had been developing γ-secretase modulators for the treatment of Alzheimer's disease, has closed its doors...

  
Newborn Neurons Abundant in Adult Human Hippocampus
7  June 2013. Using carbon-14 to estimate the age of neurons, researchers calculate that the human brain produces around 700 new neurons per day...

  
Brain Changes Speak Volumes About Normal Aging and Dementia
7  June 2013. Brain atrophy plagues more than just people with neurodegenerative disorders...

  
Methylation a Turn Off for Disease Gene C9ORF72?
6  June 2013. Since the discovery of nucleotide repeats in the C9ORF72 gene, the hexanucleotides have presented a puzzle for scientists...

  
Single-Blind Trial: Diabetes Drug Helps Parkinson’s, Maybe
3  June 2013. Could an approved diabetes medication treat Parkinson’s disease?...

  
Does Shrinking Temporal Lobe Make AD Patients Overly Sensitive?
31  May 2013. Though typically seen as a cognitive disorder, Alzheimer’s disease can throw emotions off kilter, making people unusually sensitive to others’ feelings and moods...

  
G8 to Set Sights on Dementia
31  May 2013. This June, leaders from the globe’s eight richest countries, the G8, will assemble to discuss major economic issues—among them, the rising threat of dementia in aging populations...

  
Alzheimer’s Disease Snags High-Profile Prize
29  May 2013. The focus of the next XPRIZE is Alzheimer’s disease...

  
The Power of Three: Genetic Trios Yield ALS Gene Candidates
29  May 2013. The May 26 Nature Neuroscience online debuts 25 new candidate genes for amyotrophic lateral sclerosis...

  
Limited Protein Shapes May Explain Drug Side Effects
28  May 2013. A new study explains why many drugs come with similar side effects...

  
Aβ Fibrils Drive Oligomer Formation, New Model Suggests
24  May 2013. As attention shifts toward free-floating Aβ oligomers as the prime molecular culprits in AD, there is still plenty of confusion over the role of fibrillar amyloid...

  
Finally, Therapies Targeting Huntingtin Poised for Clinic
24  May 2013. Twenty years after the identification of the mutant gene that causes Huntington’s disease, scientists are ready to take therapies that target it into human trials...

  
A Protein-Based Study of Parkinsonism’s Incidence
24  May 2013. In a study, scientists included rare types of parkinsonism and categorized them by their underlying proteinopathy...

  
Bexarotene Revisited: Improves Mouse Memory But No Effect on Plaques
23  May 2013. Researchers reported in 2012 that the cancer drug bexarotene swiftly cleared amyloid-β and restored memory in transgenic mouse models of Alzheimer's disease...

  
Paper Alert: B Vitamins Slow Atrophy in AD Vulnerable Brain Regions
23  May 2013. Results of a two-year clinical trial suggest that a mixture of B vitamins slows atrophy up to sevenfold in areas of the brain that are vulnerable to degeneration in AD...

  
Controlling Blood Pressure May Lower Amyloid in ApoE4 Carriers
22  May 2013. Scientists report that reducing hypertension may ward off amyloid pathology in people who have the ε4 version of the ApoE gene...

  
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PIB PET in early AD patient reveals amyloid in cortex and deep brain areas.[Video courtesy of Scott Ziolko and the Pittsburgh Amyloid Imaging Group]
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