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1 to 25 of 2229 results

Abnormal Mitochondrial Dynamics—Early Event in AD, PD?
5 February 2010. Mitochondria take the stage in three recent papers...

Think You Know γ-secretase and p25? Think Again
5 February 2010. There are times in the course of scientific enterprise when researchers must re-evaluate their hypotheses in the face of new, unexpected data...

Going Wild About the Latest TDP-43 Mouse Models
4 February 2010. The new animal models for TDP-43 proteinopathies, a series of related neurodegenerative diseases, are coming out at a fast and furious rate...

Shape-shifting Prions: Infectious Recombinant and Myelin-Minding Normal
3 February 2010. The cellular prion protein has received a lot of attention recently for its potential role in amyloid-β (Aβ) toxicity...

Copper Mountain: Death and Trophin Receptors—New Insight, New Drugs?
3 February 2010. Death and taxes are reputedly inevitable, though death and receptors may be more interesting to Alzforum readers...

Copper Mountain Brief: Rat-a-tat—New Model Comes a Knockin’
1 February 2010. Bigger, smarter, and more amenable than mice to the imaging techniques that are rapidly becoming indispensable in AD research, rats could be a valuable model for studying AD...

Copper Mountain: Knight Vision—SIRT1 Aids ADAM10, Slays Aβ
1 February 2010. Gizem Donmez reported that SIRT1 might protect against AD by boosting ADAM10 (aka α-secretase) and promoting non-amyloidogenic processing of Aβ APP...

Mind Your Magnesium—Oral Compound Boosts Cognition in Rats
29 January 2010. While too little calcium can trigger bone problems, insufficient magnesium may spell trouble for your brain...

NMDA Receptors Play Good Cop, Bad Cop in Huntington’s Model
29 January 2010. NMDA receptors populate the synapse, where they participate in nerve signaling and promote cell survival pathways; but those same receptors can activate apoptosis...

Research Brief: There’s a Fly in My TDP-43 Research
29 January 2010. A fruit fly is joining the menagerie of TDP-43 animal models, bringing the power of Drosophila genetics to the lab bench...

Research Brief: From Fibroblast to Neuron in One Easy Step
29 January 2010. It’s time to cut out the middleman—why go from fibroblasts, to induced pluripotent stem cells, to neurons, if one can skip straight to the payload?...

Research Brief: Cerebral Blood Flow Ebbs In Aging E4 Carriers
28 January 2010. Though ApoE4 genotype has for years topped the list of genetic risk factors for AD, scientists grapple with how this allele makes people more prone to AD...

In Veterans, Blood Pressure Meds Delay Dementia
26 January 2010. In an organ as highly vascular as the brain, optimal performance depends on keeping the plumbing shipshape...

Model Shows Oligomers Impair Memory, Questions Role of Prion Protein
25 January 2010. When it comes to the synaptic toxicity and cognitive dysfunction in AD, a preponderance of evidence points to soluble oligomers of Aβ peptides as the main villains...

Copper Mountain: Can CREB Save Memory?
25 January 2010. The Keystone Symposium at Copper Mountain, Colorado, was convened to discuss therapeutic approaches to Alzheimer disease besides those that target amyloid-β...

TDP-43: Modified and On the Move
22 January 2010. TDP-43, normally a mild-mannered nuclear protein, morphs into a cytoplasmic super villain in TDP-43 proteinopathies...

Stem Cells Move In, Set Up Shop in Brain
22 January 2010. For stem cell therapies to work, it is not enough for a new neuron to settle down in the brain...

Inside Out—Plaques May Have Intracellular Origin
22 January 2010. Researchers have, by and large, assumed that Aβ starts aggregating outside the cell...

Blunted Sense of Smell Parallels Pathology in AD, PD
20 January 2010. Two studies revive the notion that it might be possible, quite literally, to catch a whiff of neurodegenerative disease before the body and mind slip away for good...

ARF Notable Book: The Thousand Mile Stare, by Gary Reiswig
19 January 2010. Through their research participation, the Reiswig extended family made possible the identification of presenilin 2 on chromosome 1...

Clinical Trials for ALS: Taking Stock of 2009, Looking to 2010
15 January 2010. The Alzforum presents a selection of some of the top ALS trial news of 2009—and looks ahead to 2010 and beyond...

News Brief: Biomedical Funding Dips, AD Research Feels the Pinch
14 January 2010. If your lab has been scrimping and saving lately, you are not alone...

Research Brief: Meet Drosophila’s Stinging Sister, Nasonia
14 January 2010. Drosophila geneticists with an interest in neurodegeneration can now avail themselves of a new insect model...

NFL Does About Face on Head Injury, Funds Researchers
12 January 2010. Bending to joint pressure from Congress, doctors, and the media, the NFL recently took steps to protect players with head injuries and to bolster research...

Can Yakking on Your Mobile Stop Alzheimer Disease?
11 January 2010. Phone companies will love this one; a new paper suggests that electromagnetic fields (EMFs) from cell phones can protect against AD—at least in mice...

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Copper Mountain Brief: Rat-a-tat—New Model Comes a Knockin’

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In Veterans, Blood Pressure Meds Delay Dementia

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