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ALS—A Polyglutamine Disease? Mid-length Repeats Boost Risk
28
August 2010.
Researchers have mediated a merger of sorts between two distinct neurodegenerative conditions—ALS and (SCA)—and the proteins that cause them...
Insulin Resistance Correlates With Plaque, But Not Tangle, Pathology
28
August 2010.
Having diabetes seems to drive up risk for dementia, including Alzheimer disease, but the jury has been out as to how this occurs...
Common Ground: Is Aβ the Foundation for Multiple Dementias?
27
August 2010.
The majority of patients with Parkinson disease eventually develop dementia, but what pathology underlies this decline?...
New Theory for Some ALS Cases—SOD1 Plugs Cell Power Plants
27
August 2010.
The misfolded enzyme that causes some kinds of amyotrophic lateral sclerosis poisons motor neurons by plugging up pores in their mitochondria...
Putting the Squeeze on Vascularization—A Link Between Cancer and Aβ?
27
August 2010.
Several studies have shown that Alzheimer’s patients appear to be less susceptible to cancer, but the mechanism behind this association remains mysterious...
Off Key—Aβ Detunes the Theta Rhythms of the Hippocampus
25
August 2010.
Surprisingly little is known about how AD affects the electrical activity of the hippocampus...
TDP-43 and Tau Entangle Athletes’ Nerves in Rare Motor Neuron Disease
25
August 2010.
Getting hit in the head might not just ring your bell—in rare cases, it may predispose athletes in contact sports to motor neuron disease...
Another Step in the Protein Aggregation Recipe
22
August 2010.
There is a new ingredient in the complex mix that yields masses of malformed proteins...
A Toll on Memory: New Role for Immune-Related Receptor in Brain
22
August 2010.
Mounting evidence suggests that immune system molecules can wear different hats in the central nervous system...
Getting to First BACE: BACE1 Inhibition Takes a Step Forward
20
August 2010.
Inhibition of the β-secretase enzyme has long been seen as one of the most promising therapeutic options for Alzheimer disease...
Lilly Halts IDENTITY Trials as Patients Worsen on Secretase Inhibitor
18
August 2010.
Eli Lilly and Company announced yesterday that it has halted its Semagacestat γ-secretase inhibitor program...
Paper Alert: Malformed Mitochondria in the Latest TDP-43 Mouse
16
August 2010.
There is a new TDP-43 mouse in town...
γ-Secretase Modulators—More Substance for Substrate Theory
16
August 2010.
A γ-secretase inhibitor that doesn’t block γ-secretase may seem like a bit of an oxymoron, but there are some compounds that appear to do just that...
Protein Aggregation: It’s Not Just for Disease Anymore
15
August 2010.
A new study suggests that age-related protein aggregation might be widespread even in healthy organisms...
Triple Confirmation: AD Footprint in CSF of Cognitively Normal People
15
August 2010.
In clinical research, a first-time finding may rouse intrigue, but it’s generally independent confirmations of the data that give them potential to leave an indelible mark...
Honolulu: Biomarker Profiles That Spell Trouble for ‘Normals’?
13
August 2010.
Scientists have drafted a new set of diagnostic research criteria redefining AD as a condition that develops decades prior to obvious symptoms...
Anti-Aβ Oligomer Headed for Phase 3 Clinical Trial
13
August 2010.
Top-line data announced this week from a Phase 2 clinical trial of the drug scyllo-inositol give cause to move to Phase 3...
Research Brief: Lithium for ALS—Another Nail in the Coffin?
13
August 2010.
Yet again, lithium has failed to live up to its promise in the treatment of amyotrophic lateral sclerosis...
DBS Update: Attempting to Stimulate Memory in Alzheimer’s
11
August 2010.
Researchers are sliding electrodes into the brains of people with Alzheimer disease, hoping to awaken memories and stave off disease-induced forgetfulness...
Honolulu: Monkey, Rat Join Menagerie of Mammalian AD Models
11
August 2010.
Beyond the lab mouse, AD researchers may have access to a growing repertoire of brainier, brawnier species for their in vivo studies...
Paper Alert: Grappling Globulomers Improves Mouse Cognition
8
August 2010.
Antibodies to synthetic Aβ oligomers, or “globulomers,” improve cognition in a mouse model of Alzheimer disease...
Research Brief: FUS Rears Its Head in Juvenile ALS, Too
8
August 2010.
ALS is tragic when it hits in late or middle age, but a rare juvenile form of the disease is all the more devastating...
Paralysis Lost: Acting-Out Dreams Precede Parkinson’s Dementia
6
August 2010.
Paralysis is not always a bad thing—during sleep, it is essential to prevent us from acting out our dreams...
Honolulu: Neuroregeneration Taps Glia, Neurotrophins
4
August 2010.
New data from several independent studies suggest using neural stem cells to patch wide swaths of failing brain circuitry in AD may have a fighting chance...
Noisy Response Greets Revised Diagnostic Criteria for AD
4
August 2010.
Three groups presented results of their ongoing effort to incorporate scientific advances of the past quarter-century into a revision of the current diagnostic AD criteria...