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1 to 25 of 3274 results
RNA Twist: C9ORF72 Intron Expansion Makes Aggregating Protein
8  February 2013. Since the identification of the major ALS and FTLD gene C9ORF72 more than a year ago, scientists have been hunting for clues as to how it promotes disease...

  
Mistaken Identity—Prion Disease or Alzheimer’s on Fast Forward?
8  February 2013. Though considered a strange beast in the grand scheme of brain disorders, could rapidly progressing dementia be more common than scientists think?...

  
Harvard Secures $100M to Study Brain Trauma, Other Football Injuries
8  February 2013. Harvard University will lead a $100 million research effort to study chronic traumatic encephalopathy and a host of other devastating health problems in professional footballers...

  
Research Brief: Octapharma IVIg Iffy in Phase 2 Trial
8  February 2013. Aside from a reasonable safety profile, the first published Phase 2 study of a blood-derived antibody preparation to treat Alzheimer’s disease looks inconclusive at best...

  
Who Will Progress to AD? Brain Microstructure Offers Clues
7  February 2013. Subtle alterations in the brain may help predict if people with mild cognitive impairment (MCI) will progress to Alzheimer’s disease...

  
In Case You Wondered: Neurodegenerative Diseases Are Not Contagious
7  February 2013. Mounting evidence suggests that toxic proteins that cause Alzheimer's, Parkinson's, and other neurodegenerative diseases spread from neuron to neuron through the brain...

  
HAI—Aβ: First in Alzheimer’s Cascade, or Just Another Player?
6  February 2013. Scientists worldwide now perform amyloid imaging on scores of research participants to figure out how Aβ buildup relates to other markers of neurodegeneration...

  
New Assays for Aβ Oligomers—Spinal Fluid a Miss, Brain Awash
5  February 2013. Like a blue moon, could oligomeric amyloid-β in the cerebrospinal fluid (CSF) be too rare to be informative?...

  
No Hill of Beans: AlzRisk Adds Obesity, Expands Diabetes
4  February 2013. Did you ever wonder what all the studies on weight and Alzheimer’s amount to at the end of the day?...

  
Truncated Tau Triggers Tangles, Transmits Pathology
4  February 2013. What transforms tau from a well-behaved protein into a rogue?...

  
HAI—Standardizing Amyloid PET: The Centiloid Project
1  February 2013. A centiloid is a proposed unit of measure on a unified scale for all amyloid-β imaging tracers used in positron emission tomography (PET)...

  
HAI—Sharper Curves: Revamping a Biomarker Staging Model
1  February 2013. Clifford Jack's hypothetical model showing biomarkers emerging at different stages of AD surged to the top of the Most-Popular-Slide-at-Conferences chart...

  
Not So Fast: Amyloid PET Needs More Data Before Insurance Pays
31  January 2013. Your health insurance may not cover brain amyloid scans anytime soon...

  
C9ORF72 Function: Is the ALS Protein a Membrane Traffic Cop?
31  January 2013. C9ORF72, made by the ALS-linked gene of the same name, finally has a job description: According to two recent studies, it regulates membrane trafficking...

  
HAI—Amyloid Imaging in the Clinic: New Guidelines and Data
29  January 2013. Since the FDA approved the Aβ imaging agent florbetapir (Amyvid®) last April, academics and doctors have debated how it should be used...

  
Potamkin Prize Honors Work in Prevention, Biomarkers
28  January 2013. The 2013 Potamkin Prize for Research in Pick’s, Alzheimer’s, and Related Diseases will go to three neurologists who have helped advance human longitudinal studies of AD...

  
One Protein Fits All? Non-AD Epilepsy Models Thrive Sans Tau
25  January 2013. The results of a study extend the benefits of reducing the protein to mouse and fly epilepsy models whose Aβ levels and cognition are normal...

  
HAI—Spotlight on Tau Tracers at Human Amyloid Imaging Meeting
25  January 2013. A group of 250 scientists met at the 7th Human Amyloid Imaging (HAI) meeting to share the most up-to-date research on brain imaging...

  
Low Calcium Jams Neuron-Muscle Communication in ALS Fish
25  January 2013. A dearth of calcium appears to silence nerves attempting to communicate with muscles in a zebrafish model expressing a mutant version of the ALS gene TDP-43...

  
Paper Alert—HORIZON Trial Data Published
22  January 2013. Researchers have formally published the results of the Phase 3 trial of Dimebon®, aka latrepirdine, in Huntington’s disease patients...

  
Cut to the Chase: Therapies Go Directly to Central Nervous System
22  January 2013. A growing number of neurosurgeons are inserting needles, catheters, and capsules into the brain or spinal cord, hoping to alleviate AD and other neurodegenerative conditions...

  
Research and Recreational Genetics Collide to Breach Privacy
18  January 2013. Researchers report that it is surprisingly easy to breach anonymity for some individuals in U.S. genetic research databases...

  
Mutations Link Cerebellar Ataxia, Spastic Paraplegia to Lipid Biology
18  January 2013. In the case of two sets of authors, one group says “cerebellar ataxia with spasticity,” while the other says “spastic paraplegia with ataxia”...

  
NIH Funds Four Clinical Trials in ADCS Renewal
18  January 2013. The National Institutes of Health announced that it will fund the Alzheimer’s Disease Cooperative Study to conduct four new clinical studies over the next five years...

  
Solanezumab Selected for Alzheimer’s A4 Prevention Trial
18  January 2013. Researchers announced the selection of solanezumab as the first therapeutic drug to be evaluated in the A4 prevention clinical trial...

  
1 to 25 of 3274 results
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Brain on Fire
PIB PET in early AD patient reveals amyloid in cortex and deep brain areas.[Video courtesy of Scott Ziolko and the Pittsburgh Amyloid Imaging Group]
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