Alzforum News The Alzheimer Research Forum, a dynamic online scientific knowledge base, reports on the latest Alzheimer's scientific research and develops databases of genes, scientific articles, animal models, antibodies, medications, grants, research jobs, and more. http://www.alzforum.org/ Copyright © 1996-2010 Alzheimer Research Forum en-us http://www.alzforum.org/images/header_1a.gif Alzheimer Research Forum http://www.alzforum.org/ 170 72 ALS GWAS Confirm Chromosome 9 Risk Factor—But What Is It? Two genetic studies point squarely at the p arm of chromosome 9, where lurks an important risk factor for ALS... http://www.alzforum.org/new/detail.asp?id=2553 6 Sep 2010 00:00:00 EST Myosin and Memory: Motor Protein’s Major Role in Synapse Remodeling Enhancing synaptic function might be a promising strategy to treat or prevent AD... http://www.alzforum.org/new/detail.asp?id=2552 5 Sep 2010 00:00:00 EST Noradrenaline: Fueling Microglial Fight against Aβ The neurotransmitter norepinephrine seems to help resident phagocytes clear the Aβ peptides that accumulate in the brains of Alzheimer disease patients... http://www.alzforum.org/new/detail.asp?id=2551 3 Sep 2010 00:00:00 EST Behavioral Approach Improves Life for Dementia Patients, Caregivers Non-pharmacologic approaches, such as one reported in this week’s JAMA, may yet offer the best hope for finding peace amid mental decline... http://www.alzforum.org/new/detail.asp?id=2550 3 Sep 2010 00:00:00 EST Stable Aβ Oligomers?—A Little Protein Engineering Goes a Long Way Researchers report that covalently constraining Aβ monomers into a specific β-hairpin structure accelerates formation of toxic oligomers... http://www.alzforum.org/new/detail.asp?id=2549 3 Sep 2010 00:00:00 EST There’s a GSAP for That: Novel APP Partner a New Therapeutic Target? A paper reports the discovery of a γ-secretase activating protein (GSAP) that acts specifically to promote the binding of γ-secretase to APP, but not to Notch... http://www.alzforum.org/new/detail.asp?id=2548 3 Sep 2010 00:00:00 EST α-Synuclein’s Day Job: To Chaperone SNARE Complexes? To release neurotransmitters, nerve terminals must repeatedly break down and rebuild specialized protein complexes, and the fidelity of this process may rely on α-synuclein... http://www.alzforum.org/new/detail.asp?id=2547 2 Sep 2010 00:00:00 EST ALS—A Polyglutamine Disease? Mid-length Repeats Boost Risk Researchers have mediated a merger of sorts between two distinct neurodegenerative conditions—ALS and (SCA)—and the proteins that cause them... http://www.alzforum.org/new/detail.asp?id=2546 28 Aug 2010 00:00:00 EST Insulin Resistance Correlates With Plaque, But Not Tangle, Pathology Having diabetes seems to drive up risk for dementia, including Alzheimer disease, but the jury has been out as to how this occurs... http://www.alzforum.org/new/detail.asp?id=2545 28 Aug 2010 00:00:00 EST Common Ground: Is Aβ the Foundation for Multiple Dementias? The majority of patients with Parkinson disease eventually develop dementia, but what pathology underlies this decline?... http://www.alzforum.org/new/detail.asp?id=2544 27 Aug 2010 00:00:00 EST