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Brief: NFL Survey on Dementia Splashes Across Front Pages
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30 September 2009. Today’s news media are abuzz with reports, and the blogosphere with opinion, about a new phone survey on dementia commissioned by the National Football League. Conducted by the University of Michigan's Institute for Social Research, the survey at this point is neither peer reviewed nor published, but apparently was leaked to The New York Times. According to the Times story, the survey indicates that diagnoses of Alzheimer disease or other memory disorders among 1,063 retired NFL players greatly exceeded the rate expected for their age groups in the general population—by up to 19-fold among men in their forties and fifties and by fivefold among players older than 50. Despite the technical limitations of the study, it represents an acknowledgement by the league that there is a connection.
The survey comes in the wake of pressure from scientific studies and media reports that has been building over the past two to three years. The cumulative evidence, together with some high-profile individual cases, highlighted the need to study the possible risk of long-term neurologic consequences from repeated blows to the head and to institute protective measures. The Alzforum has covered the topic in the news and with a Live Discussion that was attended by, among others, Ira Casson, co-chairman of the NFL’s concussions committee (search for Casson in transcript). Casson in the past has downplayed evidence linking football and dementia. The NFL is conducting its own study; today’s NYT story notes that Dr. Casson is conducting all neurologic examinations in this study.
Newspapers, television stations, and blogs across the country picked up the NYT report. A story in the Baltimore Sun notes that ARF advisor Peter Davies, a leading pathologist in the field of neurodegenerative diseases, played a role in swaying the NFL’s concussion committee to rethink its stance after viewing slides with Bennet Omalu and Julian Bailes, two of the physician-researchers who study the issue (see prior ARF related news story). A story on NBC Miami mentions local NFL players who are deciding to donate their brains and spinal cords to a research program at Boston University’s Center for the Study of Traumatic Encephalopathy (see ARF related news story; LA Times story). And coaches and team doctors outside of professional football are taking sports concussions more seriously, too. On September 15, National Public Radio broadcast a report about schools instituting concussion management programs.—Gabrielle Strobel.
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Comments on News and Primary Papers |
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Comment by: Ann McKee
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Submitted 3 October 2009
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Posted 3 October 2009
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I offer my comments with the caveat that I have not seen the study and the study has not been peer reviewed. However, the findings as
reported by The New York Times are not surprising, and are completely
congruous with our observations at the Boston University Center for
the Study of Traumatic Encephalopathy. The brains of all seven NFL
players that we have examined have had a distinctive, widespread tau
neurofibrillary degeneration distributed throughout the cerebral
cortex, deep nuclei, and brainstem. The neurofibrillary degeneration
found in the NFL players is identical in all respects to the pattern
of tau neurofibrillary degeneration seen in retired boxers, commonly
known as dementia pugilistica or, more recently, chronic traumatic
encephalopathy (CTE).
This pattern of tau degeneration in CTE is
unique and entirely distinct from that found in Alzheimer disease,
other tauopathies, or normal aging. Furthermore, we have found this
strikingly abnormal tau deposition in every brain from a former NFL
player that we have had the opportunity to examine despite his...
Read more
I offer my comments with the caveat that I have not seen the study and the study has not been peer reviewed. However, the findings as
reported by The New York Times are not surprising, and are completely
congruous with our observations at the Boston University Center for
the Study of Traumatic Encephalopathy. The brains of all seven NFL
players that we have examined have had a distinctive, widespread tau
neurofibrillary degeneration distributed throughout the cerebral
cortex, deep nuclei, and brainstem. The neurofibrillary degeneration
found in the NFL players is identical in all respects to the pattern
of tau neurofibrillary degeneration seen in retired boxers, commonly
known as dementia pugilistica or, more recently, chronic traumatic
encephalopathy (CTE).
This pattern of tau degeneration in CTE is
unique and entirely distinct from that found in Alzheimer disease,
other tauopathies, or normal aging. Furthermore, we have found this
strikingly abnormal tau deposition in every brain from a former NFL
player that we have had the opportunity to examine despite his
relatively young age at death (mean = 46 years). So the observation
that memory loss or cognitive impairment is found more frequently in
retired NFL athletes is entirely what we would expect given our
neuropathological findings, and we will also not be surprised if we
find the same tau neurofibrillary neurodegeneration in the brains of
individuals who suffer repeated mild head injury in association with
military service, motor vehicle crashes, or accidental falls.
Currently, CTE can only be diagnosed at autopsy; very little is known
about its clinical course, and there is no method of early detection
by neuroimaging or biomarker assay. This report, combined with our
observations, underscores the need for comprehensive longitudinal
assessment of athletes and other individuals who suffer mild head
injury so that we may find a potential therapy for early intervention,
and reduce, or entirely prevent, this devastating disorder.
 View all comments by Ann McKee |
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Comment by: Christopher Nowinski
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Submitted 3 October 2009
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Posted 3 October 2009
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I offer my comment with the caveats expressed by my colleague Dr. Ann McKee. From the perspective of someone involved in the research and who also has been exposed to similar trauma as the players in the study, the findings are not surprising, but at the same time very alarming. I was most surprised by the fact that less than 2 percent of the under 50 group had been diagnosed with memory-related diseases. Due to the evolution of the way the game has been played and the “bigger, stronger, faster” nature of modern players, I believe that the current generation of athletes, despite the new concussion awareness of the last few years, is experiencing more brain trauma than any previous generation. Considering that every brain Dr. McKee has analyzed, professional or college, has had tau degeneration, with a mean age of 46, I expect more and more players will continue to show clinical symptoms early and be diagnosed with these disorders before the age of 50. Although a risk factor of 19 times versus the normal population seems astronomical, I wouldn't be surprised to see it get worse.
View all comments by Christopher Nowinski |
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Comment by: Gregory Marlow
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Submitted 7 January 2010
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Posted 14 January 2010
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The concept of mechanical injury being responsible for Alzheimer’s is consistent with the hyponatremia hypothesis I left on the Hypothesis Factory a while ago. In my hyponatremia hypothesis, repeated osmotic swelling of the brain rather than impact to the skull causes mechanical injury. View all comments by Gregory Marlow |
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