Karen Hsiao Ashe directs the Center for Memory Research and Care at the University of Minnesota, and for her this Prize comes hard on the heels of a MetLife Award she received earlier this year. The Alzforum covers Ashe’s research into the molecular correlates of AD-related learning and memory deficits closely; for her most recent paper on an oligomeric form of Aβ, see Aβ*56 story and discussion. Ashe is now focusing on characterizing a pre-tangle form of tau that might cause memory deficits.

Karen Duff is at the Center for Dementia Research at the Nathan S. Kline Institute for Psychiatric Research in Orangeburg, which is part of the New York State Office of Mental Health. As has Ashe, Duff has developed several different animal models to study the role of APP/Aβ and of tau in the pathogenesis of AD. Duff has in recent years focused on using these models to test new treatments for neurofibrillary pathology, such as kinase inhibitors and lithium (e.g., Noble et al., 2005), as well as Aβ sequestration approaches.

Brad Hyman is at Massachusetts General Hospital in Charlestown. Though Hyman’s work ranges widely, he is perhaps best known for his early work displaying the damage to the neuronal system that accounts for the behavioral signs of AD, and more recently for his talent in developing clever ways of imaging disease progression in animal models; see Christie et al., 2001). All three scientists collaborate on occasion (see, e.g., Urbanc et al., 2002). Warmest congratulations to the two Karens and Brad!

Funded by the philanthropic Potamkin Foundation, the prize last year went to John Morris at Washington University, St. Louis, Missouri, and Ronald Petersen at the Mayo Clinic College of Medicine in Rochester, Minnesota, for their work on early diagnosis of AD.—Gabrielle Strobel, adapted from press releases.