Amyloid Ligand Looks Suited for Future Diagnostic Test
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This four-dimensional image represents the XYZ axes and time in a tiny area of cortex from a live APP-transgenic mouse, minutes after it has received an injection of the fluorescent amyloid marker PIB into its tail vein. The plaque fills in from the outside (yellow) to the core (red) as the dye penetrates from the parenchyma.
This multiphoton recording shows the kinetics of PIB's distribution. The pseudocolors represent different time points in a movie sequence Three distinct time points are shown here simultaneously as projections of their respective 3-D volumes. Blue pseudocolor corresponds to where the dye was visible immediately after IV injection, green shows it after five minutes, and red at 15 minutes. PIB enters the brain, is rapidly cleared from blood vessels, and targets vascular and parenchymal amyloid deposits with high specificity, making it a suitable in-vivo biomarker. The plaque in the center of the image—approximately 75 microns in diameter—is labeled from the outside in over time, becoming completely filled by 15 minutes.
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