Senior Scientist/Principal Scientist, Histochemistry and Pathology
Posted 05 Nov 2013
Awa Bernard - firstname.lastname@example.org
Our challenge. Your impact.
We aspire to be the patient-centric global biopharmaceutical leader, transforming the lives of people with severe diseases and need exceptional individuals to achieve this goal. We are looking for enthusiastic and talented professionals who thrive on challenge and change, who want to make a difference and deliver results.
We currently have an exciting role for an outstanding biologist to work within the neuroscience therapeutic area, engaging in breakthrough drug discovery research in a vibrant environment—inspired by patients, driven by science.
The successful candidate will engage in the treatment of neurodegeneration across a number of diseases:
- Develop critical assays supporting research in neurodegeneration and drug development.
- Work across sites and functions and with external parties to move projects forward.
As an experienced immunohistochemist, the candidate will:
- Design, implement, and run studies to analyze the effects of experimental interventions and drugs on the brain, addressing a variety of readouts such as changes in pathological deposits, cell number, neuronal projections, neuroinflammatory processes, and protein and gene expression using a variety of methods.
- Play a critical role in the design of target engagement, mechanism of action, and in-vivo pharmacology studies.
- Coach and train scientific staff in the use of new technologies
- Be prepared to be a project champion and team leader
- Represent and promote UCB research activities at internal and external scientific meetings and by publishing studies in peer-reviewed journals
- Develop a strong network with academic experts and initiate and run external studies and collaborations.
- PhD in neuroscience
- Postdoctoral experience in neurodegeneration coupled with an excellent publication record
- Expertise in neurobiology with a focus on neurodegeneration
Knowledge and experience of a wide range of immunohistochemistry, including methods for quantitation: specific cell and fiber staining (specific neurons, reactive glia, dendrites, axons), determination of cell number and regional volume changes, protein and gene expression and localization, neuroinflammation, autoradiography, staining of membrane proteins, synapse dynamics.
Technically, the candidate should have experience in various aspects of tissue preparation, be familiar with current technologies of sectioning and microscopy, especially fluorescence and confocal microscopy, and be able to extend current platforms and knowledge.
- English required, French desirable
- Strong analytical skills
- Inspirational and oustanding scientist with an innovative and entrepreneurial spirit
- Dynamic and passionate about science