Scientist/Senior Scientist, PD Biomarkers—Neuroscience


Genentech, Inc.


South San Francisco, California, U.S.A.



The department of Pharmacodynamic (PD) Biomarkers is responsible for developing  strategy, designing and implementing biomarker assays, and interpreting PD biomarker results.  Biomarker team leaders within the department also provide scientific leadership for diagnostic biomarkers in clinical development. We are currently seeking a highly motivated scientist to provide PD and diagnostic biomarker support on both small molecule and biologics projects in neuroscience and ophthalmology indications. 

This senior scientist will be responsible for defining PD biomarker strategies and developing and implementing PD biomarker assays for use in pre-clinical and clinical research. A thorough understanding of disease and drug target biology, creativity and attention to detail to develop novel biomarker assays, and a pragmatic approach to integrating biomarkers into clinical trials are required.  The position requires working in close partnerships across various functions including research, preclinical PK, clinical pharmacology, bioanalytical assays, diagnostics discovery, companion diagnostics, clinical sciences, biostatistics, and regulatory.  The candidate will serve as the PD biomarker representative on cross-functional project teams and lead subteams that integrate all biomarker activities for projects in development.  In addition to strong scientific skills in translational biology/pharmacology, this individual must have strong leadership and managerial skills.  Effective communication is essential and includes presentations at cross-functional teams, internal review committees, and external conferences, and writing biomarker sections of clinical protocols, reports, regulatory filings, and scientific publications.  In addition, the individual is expected to establish and manage relevant and productive collaborations with academic researchers and contribute to the scientific community by publishing results in high quality journals.


Candidates must have a Ph.D. or M.D./Ph.D. in neuroscience, biology, pharmacology, biochemistry, or a related field with at least three years of industrial or relevant academic experience. Preferred candidates will have experience working on pre-IND and clinical project teams and significant technical experience in the development, implementation, and interpretation of biomarker assays in clinical trials.  Expertise in bioanalytical methods, such as multiplex immunoassays, qPCR, and/or mass spectrometry, is highly desirable. Experience in analyzing complex multivariate datasets is also preferred.  The candidate must have excellent communication skills and the ability to work on interdepartmental project teams. A record of cutting-edge research related to neurodegeneration, psychiatric diseases, retinopathy, or PD/diagnostic biomarkers as demonstrated by publications in top tier journals and external presentations is required. Applicants with additional experience are encouraged to apply.