Jobs

Postdoctoral Researcher for Project on New Approach to Treat Alzheimer's Disease

Employer

Karolinska Institutet

Location

Solna, Sweden

Principal Investigator

Jan Johansson 

Contact

Prof. Jan Johansson (janne.johanson@ki.se, tel +46-703457048)

Description

The project aims to harness the BRICHOS domain for treatment of Alzheimer's disease. The research team has found that the domain has a unique mechanism of action—it redirects the fibrillation pathway so that generation of toxic oligomers from the Aβ is markedly reduced. Recent data show that recombinant BRICHOS can pass the blood-brain barrier, and the team will now study how administration of BRICHOS to state-of-the-art APP-knock-in Alzheimer's mouse models affects neuropathology and behavior. Two groups, one focused on protein aggregation and one with expertise on mouse models of Alzheimer's disease, will run the project jointly. Currently the groups have about 20 members, including professors, senior scientists, postdocs and graduate students with a broad international background.

Requirements

Eligible candidates must have obtained a Ph.D. in (bio)medicine, cell biology, biotechnology or similar topic, no more than seven years before the last date of employment as postdoc. The term can be extended under special circumstances. The postdoc to be recruited needs to have strong experience of working with mouse models, in particular using invasive methods, and a good knowledge of neurodegenerative diseases. Experience from behavioral studies, immuno-histochemistry and immunofluorescence methods, and studies of neuroinflammation are required.

For more information and to apply, go to https://ki.mynetworkglobal.com/what:job/jobID:136110/.