Jobs

Postdoctoral Research Associate in Neurodegeneration

Employer

King's College London

Location

London, England, United Kingdom

Principal Investigator

Diane Hanger

Contact

The selection process will include a presentation and a panel interview. Interviews are expected to be held early April 2017. For an informal discussion to find out more about the role please contact Professor Diane Hanger. To apply for this role, please go to the King’s College London HireWire Job Board and register to download and submit the specified application form. The deadline for applications is midnight on 23 March 2017.

Description

King's College London is seeking a highly motivated postdoctoral research associate to join the Department of Basic and Clinical Neuroscience at the Institute of Psychiatry, Psychology & Neuroscience.

The post is funded by the Alzheimer’s Society for three years. The research group has developed a new mouse model that researchers are using to investigate molecular mechanisms underlying the development of neurodegenerative diseases, such as Alzheimer’s disease and related disorders (Bondulich et al., 2016). In particular, the researchers are examining the influence of tau on disease mechanisms and cognitive processes. The aim of this project is to establish primary neuronal cultures from this tauopathy model and test the adverse effects of expressing a disease-associated tau fragment. The researchers have shown previously that tau is released by neurons and that this process is critically dependent on both calcium and neuronal activity. This project will examine the effects of expressing a tau fragment on basal and stimulated tau release from neurons. It will also examine the influence of the tau fragment on synaptic proteins and the development of dendritic spines in cultured neurons, which is important for disease pathogenesis in dementia.

Requirements

Experience in working with transgenic mouse models and primary neurons using advanced microscopy, biochemical, cell, and molecular biology approaches would be advantageous. A good knowledge of defective signaling processes in dementia and related disorders is also required for this post. The successful applicants will join established research groups headed by Diane Hanger and Wendy Noble.