Postdoctoral Research Associate


University of Cambridge


Cambridge, England, United Kingdom

Principal Investigator

William McEwan


Please contact Heather Carlyon with questions about this vacancy or the application process.


An opportunity has arisen to join the Cytosolic Protein Targeting Group at the U.K. Dementia Research Institute, hosted in the Department of Clinical Neurosciences at the University of Cambridge. This group is headed by Will McEwan and investigates cellular mechanisms that can bring about the selective degradation of pathogenic proteins in the cytosol. A major goal is in using intracellular immunity to selectively target assemblies of tau, a protein that aggregates during Alzheimer's disease.

The postdoc will seek to understand how therapeutic antibodies operate against the spread of tau misfolding through the brain. Particular attention will be paid to the role of TRIM21, the recently discovered, dedicated antibody receptor of the cytoplasm. The work will build on recent findings that TRIM21 can prevent the spread of tau misfolding (McEwan et al., 2017). Research in several experimental systems will be performed, including cell-based and in vivo settings. Experience in cellular, biochemical, or animal techniques is therefore advantageous. 


The post-holder must hold a Ph.D. or equivalent in a relevant field (or be in the course of finishing his or her Ph.D).