Jobs

Postdoctoral Position in Pharmacology

Employer

Emory University

Location

Atlanta, Georgia

Principal Investigator

Thota Ganesh

Contact

Interested candidates can send a CV, cover letter describing interests, experience and date of availability, and contact information of three references, to Dr. Thota Ganesh at tganesh@emory.edu or to Dr. Ray Dingledine at rdingle@emory.edu.

 

Description

A Ph.D. level postdoctoral position with a focus on studying phenotypes and therapeutic efficacy of small molecules on Alzheimer’s disease models is available in the laboratory of Dr. Thota Ganesh and Dr. Ray Dingledine at the Department of Pharmacology, Emory University School of Medicine.

The successful candidate will play a key role in experimental design, data collection, and analysis. He/she will collaboratively work with a multidisciplinary team of neuroscientists and medicinal chemists to acquire biochemical and histochemical data from in vitro and in vivo animal models.

The specific responsibilities of this position include:

  • Treating rodents with investigational drug candidates for weeks to months and studying behavioral deficits, harvesting the blood and brain at the end point for analysis.
  • Analysis of brain inflammation and neuropathology by ELISA, western-blot, qRT-PCR, immuno-histochemistry to study amyloid plaques, soluble amyloids, gliosis and neurodegeneration.

Requirements

  • Ph.D. in molecular and neurobiology or neuropharmacology with up to two years of postdoctoral experience in above fields. Additional experience working with transgenic Alzheimer’s rodent models will be advantageous.
  • Familiarity with rodent brain/tissue harvesting, surgical procedures, brain sectioning; use of microscope, confocal, cryostat, and PCR machines.
  • Knowledge of creation of Alzheimer’s transgenic animals, troubleshooting in genotyping.
  • Familiarity with immuno-histochemistry of gliotic markers, ELISA, and western blot techniques.
  • Cell culture work, including creation of stable cell lines using vectors/constructs, and testing the novel compounds for potency evaluation.
  • Isolation of primary cells such as microglia and macrophages from mice and rats. Characterization of phagocytosis markers in the cells microglia will be a plus.
  • Knowledge of statistical methods including probability and power analysis.
  • Ability to work independently in an interdisciplinary team environment.
  • Ability to discuss issues and developments with scientists with different backgrounds.
  • Good communication skills.

NIH suggested salary (0-2 year experience after Ph.D.) with fringe benefits.